PITTSBURGH — Patrick Mahomes passed for 320 yards and three touchdowns and the Kansas City Chiefs locked up the top seed in the AFC for the fourth time in seven seasons with a 29-10 win over the Pittsburgh Steelers on Wednesday.

The two-time defending Super Bowl champions raced to an early 13-point lead and were never really threatened by the Steelers (10-6), who have dropped three straight as their chances of capturing the AFC North took another hit.

Mahomes connected on first-half scoring tosses to Xavier Worthy and Justin Watson and Kansas City’s defense did most of the rest even with perennial All-Pro defensive end Chris Jones sitting out while nursing a calf injury. The Chiefs sacked Russell Wilson five times, forced two turnovers and hardly looked gassed while playing for the third time in 11 days.

The 35-year-old celebrated by dunking the ball over the goal post, which drew an unsportsmanlike conduct penalty and groans from a capacity crowd at Acrisure Stadium that has grown used to seeing Mahomes toy with the hometown team. Mahomes is now 4-0 against the Steelers in his career, with 17 touchdowns against one interception.

Russell Wilson threw for 205 yards for Pittsburgh. George Pickens finished with three receptions for 50 yards after missing three games with a hamstring injury. It wasn’t nearly enough for the Steelers, who went 0-3 during a brutal three-game stretch against Super Bowl contenders Philadelphia, Baltimore and Kansas City.

Perhaps more troubling than the losses is the way they played out. The Steelers lost each game at least 14 points and could start the playoffs on the road after playing fast-and-loose with the two-game division lead they had just three weeks ago.

Mahomes, hardly bothered by the ankle injury he suffered against Cleveland, led the Chiefs to touchdowns on their first two drives, finding Worthy in the flat for a 7-yard score and hitting Watson in the back corner of the end zone to make it 13-0.

One sequence late in the first quarter symbolized a frustrating day for Pittsburgh. A holding penalty negated a short touchdown run by Jaylen Warren and Wilson threw into triple coverage in the end zone on the next snap. Kansas City’s Justin Reid had little trouble grabbing it to end the threat.

The Steelers drew within six twice at 13-7 and 16-10, but never had the ball with a chance to take the lead in the second half. Instead, the Chiefs – who spent most of the first three months of the season squeaking by most weeks – methodically pulled away.

Kareem Hunt ran over from 2 yards on the first snap of the fourth quarter to make it 22-10. Pat Freiermuth then fumbled on Pittsburgh’s next possession. Kansas City linebacker Nick Bolton fell on it and Mahomes needed just four plays to float a pass to a wide-open Kelce to put it out of reach.

Chiefs: RB Isiah Pacheco left in the second half with a rib injury.

Steelers: DT Cam Heyward exited briefly in the fourth quarter but managed to return.

Chiefs: finish up the regular season by heading to Denver.

Steelers: host Cincinnati in the regular-season finale.