The midfielder has come off the bench in Arsenal’s last two games, getting 42 minutes under his belt.
Arsenal come into the match off the back of three huge games, with the last of those at Chelsea on Sunday.
Mikel Arteta could therefore make changes to his side, although he is short of options in the heart of defence.
“He had a little niggle, but I think it is going to be a matter of days,” said Arteta on Tuesday morning. “So, let’s see if he is able to do that tomorrow.
“The ankle one (the injury Saliba had in August) was a really random one, a very unlucky action that kept him out for a few weeks.
“He tried at Anfield and he wasn’t comfortable, and he had to stay away. And this one as well is very bizarre, but hopefully it will be a matter of days.”
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Gabriel Martinelli or Noni Madueke are primed to come in on the left flank, although Eberechi Eze could move out there.
Viktor Gyokeres is back in action and returned off the bench last weekend following a hamstring strain.
Arsenal predicted XI (4-3-3): Raya; Timber, Mosquera, Hincapie, Calafiori; Odegaard, Zubimendi, Rice; Saka, Merino, Madueke
Doubts: Saliba (knock) and Trossard (calf)
Injured: Gabriel (thigh) and Havertz (knee)
Time and date: 7.30pm GMT on Wednesday, December 3, 2025
